文献详情
Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis
文献类型期刊
作者Zhong, Hong[1];Chen, Ke[2];Feng, Mengyang[3];Shao, Wei[4];Wu, Jun[5];Chen, Kun[6];Liang, Tingming[7];Liu, Chang[8]
机构
通讯作者Liang, TM; Liu, C (reprint author), Nanjing Normal Univ, Jiangsu Key Lab Mol & Med Biotechnol, 1 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.; Liang, TM; Liu, C (reprint author), Nanjing Normal Univ, Coll Life Sci, 1 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China.
2018
期刊名称FEBS JOURNAL影响因子和分区
来源信息年:2018  卷:285  期:3  页码范围:501-517  
285
期刊信息FEBS JOURNAL影响因子和分区  ISSN:1742-464X
3
关键词genipin; hyperlipidemia; liver; miRNAs; SREBP-1c
页码范围501-517
增刊正刊
摘要Hyperlipidemia is a chronic disorder which plays an important role in the development of cardiovascular diseases, type 2 diabetes, atherosclerosis, hypertension, and nonalcoholic fatty liver disease. Genipin (GNP) is a metabolite from genipioside, which is an active component of the traditional Chinese medicine Gardenia jasminoides Ellis, and has been recognized as a beneficial compound against metabolic disorders. However, whether it can correct overnutrition-induced dyslipidemia is still unknown. In this study, the effects of GNP on attenuating hyperlipidemia and hepatic lipid accumulation were investigated using normal and obese mice induced with a high-fat diet (HFD) and primary hepatocytes treated with free fatty acids. We also sought to identify potential targets of GNP to mediate its effects in the liver. We found that obese mice treated with GNP showed a decrease in the body weight, serum lipid levels, as well as hepatic lipid accumulation. Besides, GNP regulated hepatic expression levels of lipid metabolic genes, which are important in maintaining systemic lipid homeostasis. At the molecular level, GNP increased the expression levels of miR-142a-5p, which bound to 3 untranslated region of Srebp-1c, an important regulator of lipogenesis, which thus led to the inhibition of lipogenesis. Collectively, our data demonstrated that GNP effectively antagonized HFD-induced hyperlipidemia and hepatic lipid accumulation in mice. Such effects were achieved by regulating miR-142a-5p/SREBP-1c axis.
收录情况SCIE(WOS:000424168600006)  PubMed(29197188)  
所属部门生命科学学院
DOI10.1111/febs.14349
百度学术Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis
语言外文
被引频次2
人气指数794
ISSN1742-464X
浏览次数792
基金National Natural Science Foundation of China [31422028, 31771298, 31401009, 81301616]; NSF of Jiangsu Province of China [BK20161057]; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine (Nanjing Medical University); Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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